Origins In Cells Clusters, Intercell Cleanup

Origins In Cells Clusters, Intercell Cleanup


Antidepressants show signs of countering Alzheimer’s Human brain scans and mice data link serotonin-boosting drugs with reduced plaque density.



So what else is new?

posted by Dov Henis on 15 Mar 2009, origin written 2005

Life Is Simpler Than They Tell Us


Genes to Genomes to Monocellular to Multicellular Organisms;

Direct Sunlight to Metabolic Energy, Too;

Tryptophan to Serotonin to Melatonin to Neural System. (cue for intercell
cleanup time)

A. Tryptophan to Serotonin to Melatonin

Melatonin is a hormone secreted by the human pineal gland during night-time
darkness. It is now marketed in the US as a nutritional supplement. The hormone
is an indolamine compound derived from the essential amino acid L-tryptophan,
with serotonin as an intermediate precursor.

Tryptophan is one of eight essential amino acids, not produced by the body but
coming from the diet. The additional fourteen amino acids are produced metabolically.

In the brain, tryptophan converts to serotonin, the neuro-transmitter. Tryptophan
is the only source for serotonin in the brain. Insufficient L-tryptophan in the diet is a cause of many severe biological malfunctions.

Some serotonin is converted in the pineal gland to melatonin, the hormone involved in intercell processes during sleep time.

B. Sunlight to Metabolic Energy

Bio-clocks are products of the innate sun-dictated active-inactive pattern of genes and genomes, parents of Earth’s life. During life genesis and its early evolution direct sunlight was the only source of their usable energy. This situation persisted well into the evolution of the early monocellular organisms, and both genes and genomes display, therefore, innate “inactive-sleep” phenomena.

The incorporation of mitochondria with some cells initiated the metabolic bio
production of bio usable energy and furnished the evolving monocellular organisms with new, additional, flexibly available local energy. This development opened up a variety of courses of evolutions of cultures of monocells communities.

C. Individual Monocells to Cooperative Monocells-Communities

As individual independent genes aggregated to cooperative genes communes,
genomes, so individual monocells aggregated cooperatively into monocellular communities, cultures.

“Life has always been and still is a fractal affair, repetition of phenomena on ever more complex scale. It cannot be otherwise; it evolves. And surviving-proliferating life has always been a cooperative affair since cooperation is most successful for overall survival/proliferation.”

Cooperation requires all sorts of interactions, including maintenance, protection and foraging for food-energy. Organisms’ interactions are “cultures”. Cultures require “cultural energy”. Melatonin and some proteins are dark-and-light cue signals evolved by the monocells communities for timing intercells processes when the intracells processes are at “sleep-inactive” state. Melatonin is a derivative of serotonin a derivative of tryptophan, and proteins are genes’ tools, energy-dependent
metabolism products.

D. Monocellular to Multicellular Organisms, Monocells Culture to Neural System

Now we can appreciate the fractal nature of life’s evolution. It is ever-continuous ever-enhanced ever-complexing cooperation. Now we can understand why, and grosso modo how, all the organs and processes and signals found in multicelled organisms have their origins in the monocells communities. And this includes the functions of serotonin and melatonin and, yes, the evolution of neural cells and the neural systems with their intricate outer-membrane shapes and functions and with their high energy consumption requirements.

Now, circa four billion years after initial genesis-evolution with direct sun’s energy followed with evolution with also indirect, bio, sun’s energy, some of Earth life, we humans, find ourselves short of energy and in need of exploiting again more, and more directly, our sun’s energy…

Dov Henis

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